Mr Kher, whose wife Kirron Kher is the BJP MP from Chandigarh, accused the 'Award Wapsi Gang' of being politically motivated.
He also blamed them for having had him ousted as Censor Board chief in 2004 by Manmohan Singh's UPA government.
Anupam Kher trended for a while on Thursday morning. Censor Board member Ashoke Pandit and filmmaker Madhur Bhandarkar echoed Mr Kher's sentiments.
Who funded filmmakers like#RakeshSharma #AnandPatwardhan s foreign trips regularly during the UPA rule?A matter of investigation.? Ashoke Pandit (@ashokepandit) October 29, 2015
In my view giving away the National Award is a disrespect to 1self & also 2 the actors, technicians,audience, jury members, & Hon. President? Madhur Bhandarkar (@imbhandarkar) October 29, 2015
Just wondering, ppl who r returning awards will thy not accept any appreciation or award 4 their work while Modi Govt is in power till 2019?? Madhur Bhandarkar (@imbhandarkar) October 29, 2015
Not everyone agreed with Mr Kher, however, some taking the opportunity to sneak in a joke.
Anupam Kher is confused about his profession.He is confused whether he is actor, host, protestor, politician,debater or a blind Modi bhakt? #Don't Mess With Me (@johnson_joel14) October 29, 2015
Anupam Kher says he is not a thinker. Is that Y he talks without thinking? Or he doesn't Kher?? Rasheed Kappan (@kappansky) October 29, 2015
Anupam Kher is that bigoted and outspoken uncle you want to put off introducing to your wife/girlfriend for as long as possible.? Bhavya Khanna (@bhavyakhanna) October 29, 2015
All Sahitya Akademi, Padma Bhushan, National Award winners are stupid. Only Anupam Kher is intelligent. The man is an embarrassment.? lindsay pereira (@lindsaypereira) October 29, 2015
The 60-year-old actor remained unperturbed. In response to a tweet from Congress spokesperson Priyanka Chaturvedi about 'forgetting' he won National Awards, Mr Kher said he 'respects' those who gave him his awards, for the films Daddy and Maine Gandhi Ko Nahin Mara.
U shud name me. I won't feel bad. I respect people who gave me awards. My protest is not based on hidden agendas.:) https://t.co/5adtRBVjIZ? Anupam Kher (@AnupamPkher) October 28, 2015
There were also a sizeable number of supporters for Mr Kher.
Anupam Kher the only sane voice in Bollywood who give befitting replies to #PaidMedia dalaals and pseudo seculars. Hats off to you sir. :)? Sona (@Adorable_Riti) October 29, 2015
You give a hard hitting to Pseudo Seculars and thats what is best in @AnupamPkher Anupam Kher? Kritika Singh (@Kritika_S8) October 29, 2015
Anupam Kher, who made an acclaimed breakthrough in Mahesh Bhatt's 1984 film Saaransh, has appeared in Hollywood films like Silver Linings Playbook and will soon be seen opposite Salman Khan in Prem Ratan Dhan Payo. He is also filming Neeraj Pandey's MS Dhoni: The Untold Story.