The 39-year-old, currently busy with the release of his next superhero movie Krrish 3, trashed the news about their divorce via micro-blogging website Twitter.
"Just a thought - your life is less about you and more about the people around you who love you!" he tweeted.
Sussanne's sister, jewellery designer Farah Khan Ali, too blasted the gossipmongers for spreading the bogus news on the micro-blogging site.
She wrote: "Celebrities will always be food for gossip. Don't believe everything you read. It's a pity the media lives off personal lives. Get a life!"
Sussanne and Hrithik dated for a long time before getting married in December 2000. This was the same year when Hrithik made his debut in the Hindi film blockbuster Kaho Naa Pyaar Hai.
They have two sons - Hrehaan and Hridhaan.