"Today is my first chemo... between being nervous of unknown and courage to face the challenge, I am in a state of prayer and in gratitude of the support I have received from mom, dad, Koi, (sister-in-law) Yulia... though she is far but her love and prayers do touch me," Manisha posted on her Facebook page.
"And so many other loving friends and family... thank you for your love and prayers. Nothing else is more important than love and care. Thank you... until next time," she added.
Manisha Koirala, 42, is known for her work in Bollywood films like Saudagar, 1942 A Love Story, Bombay, Dil Se and Lajja.
She underwent surgery in New York on December 10, 2012, and was discharged from the hospital after 11 days.