The news was announced on Twitter by Playboy founder Hugh Hefner's son Cooper recently, reported Aceshowbiz.
"It'll be a great issue," he tweeted.
Moss will be posing as a Playboy bunny on the cover, complete with the velvet ears, French cuffs and silk stockings, while, inside the pages, she will reportedly go full-frontal nude.
The Forbes second top-earning model for 2012, known for her waifish figure, was deemed the best choice for the special issue on account of her being a global fashion icon.
"You're talking about the face of Burberry, the biggest supermodel in the world on the cover of Playboy. She's the perfect partner for us to help launch the next 60 years," said the magazine's editorial director Jimmy Jellinek.
Hefner himself said, "It's a natural for us" to have Moss on the cover, which had been typically reserved for curvier celebrities like Marilyn Monroe, Anna Nicole Smith and Pamela Anderson".
"She's a worldwide celebrity and iconic and crosses the boundaries from sexual imagery to upscale modeling," said Hefner.