The 25-year-old was performing his song Loyal on stage at Fiesta Nightclub in San Jose, California when the incident happened leaving at least five people injured - all were rushed to hospital, reports aceshowbiz.com.
Chris was not injured and was quickly rushed to safety by his entourage as chaos broke out on the dance floor.
No suspects have reportedly been named. Police questioned a number of people to investigate the motive behind the shootings.
However, it's not his first brush with club violence.
In August 2014, an event hosted by the singer also ended in violence. Gunshots rang out when the singer hosted a pre-VMAs party at 10ak in Los Angeles, injuring music producer Suge Knight.
He was also involved in a 2013 infamous brawl with Drake over former girlfriend Rihanna.