The 32-year-old Suit & Tie hitmaker is poised for his first live performance in the UK since six years at the annual awards ceremony, reported Sun online.
"Justin will christen his comeback with a performance at the Brits. Talks between organisers, his label and management have been ongoing since the start of the year," a source said.
"Justin's team have been plotting his return carefully. He loves the UK and wants to announce his comeback with a top set. Brits bosses know that his performance, as well as Beyonce's, will bring in a huge TV audience," the source added.
The O2, where this year's Brit Awards will be held, was also the location of Justin Timberlake's UK solo shows in summer 2007.
Robbie Williams, Muse, Mumford & Sons, Emeli Sande and Ben Howard have already been announced as performers at the ceremony.
One Direction will debut their Comic Relief cover of Blondie's One Way or Another for Red Nose Day at this year's awards, while Beyonce and The Rolling Stones are both rumoured to be performing, but not yet confirmed.
Justin Timberlake was recently announced as a performer at next weekend's Grammy Awards in Los Angeles.