The director of such films as Blood Feast and Two Thousand Maniacs in his sleep at his home in Pompano Beach, Florida on Monday, said his spokesman James Saito.
Mr Lewis pioneered the horror genre in the 1960s known as the "splatter film," which intentionally focused on gore and gruesomeness.
His low-cost, envelope-pushing films unabashedly featured blood, violence and nudity.
Other horror films created by Mr Lewis includes A Taste of Blood, The Wizard of Gore, The Gruesome Twosome, She-Devils on Wheels and Scum of the Earth!.
Mr Lewis also worked in advertising and financed most of his own films.
John Waters, Robert Rodriguez, Quentin Tarantino and James Gunn are among the modern-day filmmakers who were inspired by Mr Lewis' work.
Mr Gunn posted his condolences on Twitter:
RIP Herschell Gordon Lewis, the creator of splatter films & the director of Blood Feast & 2000 Maniacs. He changed cinema.? James Gunn (@JamesGunn) September 26, 2016
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